甲硝唑联合阴道抑菌凝胶治疗细菌性阴道病的临床疗效观察(1)
【摘要】 目的 探讨甲硝唑联合阴道抑菌凝胶治疗细菌性阴道病的临床疗效。方法 100例细菌性阴道病患者， 随机分为对照组和治疗组， 各50例。对照组给予甲硝唑进行阴道填塞治疗， 治疗组在此基础上加用阴道抑菌凝胶填塞， 观察治疗1周后两组患者治疗的有效率及停药1周后复发率情况， 并进行比较。结果 治疗1周后， 治疗组有效率为90%， 对照组有效率为84%， 比较差异无统计学意义(P>0.05)；停药1周后， 治疗组复发率为30%， 明显低于对照组的50%(P<0.05)。结论 甲硝唑联合阴道抑菌凝胶用于治疗细菌性阴道病， 经观察治疗效果好、副作用少、复发率低等特点， 值得临床推广应用。
【关键词】 甲硝唑；细菌性阴道病；阴道抑菌凝胶
DOI：10.14163/j.cnki.11-5547/r.2016.29.009
Observation of clinical effect by metronidazole combined with vaginal antibacterial gel in the treatment of bacterial vaginosis CHEN Yan， OUYANG Yun-ying， FAN Jian-mei. Department of Obstetrics and Gynecology， Guangdong Foshan City Nanhai District Seventh People’s Hospital， Foshan 528247， China
【Abstract】 Objective To investigate clinical effect by metronidazole combined with vaginal antibacterial gel in the treatment of bacterial vaginosis. Methods A total of 100 patients with bacterial vaginosis were randomly divided into control group and treatment group， with 50 cases in each group. The control group received metronidazole for vaginal packing treatment， and the treatment group also received additional vaginal antibacterial gel. Observation was made on treatment effective rate after 1 week of treatment and recurrence condition after 1 week of drug withdrawal in both groups for comparison. Results After 1 week of treatment， the treatment group had effective rate as 90%， which was 84% in the control group， and their difference had no statistical significance (P>0.05). After 1 week of drug withdrawal， the treatment group had obviously lower recurrence rate as 30% than 50% of the control group (P<0.05). Conclusion Combination of metronidazole and vaginal antibacterial gel in treating bacterial vaginosis contains advantages of good curative effect， few adverse reactions and low recurrence rate. It is worth clinical promotion and application.
【Key words】 Metronidazole； Bacterial vaginosis； Vaginal antibacterial gel
细菌性阴道病是由某些厌氧菌与阴道加德纳细菌混合感染的非特异性的阴道炎症， 是由大量不同的细菌在阴道内引起的临床及病理非炎症改变， 并非阴道炎[1]。异位妊娠或不孕可由细菌性阴道病引起。另外绒毛膜炎及早产、胎膜早破、羊膜炎是导致细菌性阴道病的原因， 新生儿感染及产褥感染等严重后果也是引起细菌性阴道病的常见因素[2]。本科于2015年1月～2016年6月联合应用甲硝唑与阴道抑菌凝胶治疗细菌性阴道病， 本文对此进行研究， 报告如下。
1 资料与方法
1. 1 一般资料 选取本院2015年7月～2016年6月收治的细菌性阴道病患者100例。随机将患者分为对照组和治疗组， 各50例。治疗组年龄23～48岁， 平均年龄(32.6±12.8)岁；病程1～16 d， 平均病程(10.3±6.2)d。对照组年龄22～49岁， 平均年龄(33.4±13.1)岁；病程1～18 d， 平均病程(11.2±7.4)d。两组患者一般资料差异无统计学意义(P>0.05)， 具有可比性。
1. 2 诊断标准[3] ①病史：外阴瘙痒或烧灼感及白带增多。②妇科检查：阴道分泌物呈灰白色、稀薄、量多， 常粘附于阴道壁， 伴有鱼腥味。阴道黏膜无充血的炎症表现， 但容易从阴道壁拭去。③实验室检查： 细菌性阴道病细菌性阴道病阳性。, 百拇医药(陈艳 欧阳云英 范建美)
【关键词】 甲硝唑；细菌性阴道病；阴道抑菌凝胶
DOI：10.14163/j.cnki.11-5547/r.2016.29.009
Observation of clinical effect by metronidazole combined with vaginal antibacterial gel in the treatment of bacterial vaginosis CHEN Yan， OUYANG Yun-ying， FAN Jian-mei. Department of Obstetrics and Gynecology， Guangdong Foshan City Nanhai District Seventh People’s Hospital， Foshan 528247， China
【Abstract】 Objective To investigate clinical effect by metronidazole combined with vaginal antibacterial gel in the treatment of bacterial vaginosis. Methods A total of 100 patients with bacterial vaginosis were randomly divided into control group and treatment group， with 50 cases in each group. The control group received metronidazole for vaginal packing treatment， and the treatment group also received additional vaginal antibacterial gel. Observation was made on treatment effective rate after 1 week of treatment and recurrence condition after 1 week of drug withdrawal in both groups for comparison. Results After 1 week of treatment， the treatment group had effective rate as 90%， which was 84% in the control group， and their difference had no statistical significance (P>0.05). After 1 week of drug withdrawal， the treatment group had obviously lower recurrence rate as 30% than 50% of the control group (P<0.05). Conclusion Combination of metronidazole and vaginal antibacterial gel in treating bacterial vaginosis contains advantages of good curative effect， few adverse reactions and low recurrence rate. It is worth clinical promotion and application.
【Key words】 Metronidazole； Bacterial vaginosis； Vaginal antibacterial gel
细菌性阴道病是由某些厌氧菌与阴道加德纳细菌混合感染的非特异性的阴道炎症， 是由大量不同的细菌在阴道内引起的临床及病理非炎症改变， 并非阴道炎[1]。异位妊娠或不孕可由细菌性阴道病引起。另外绒毛膜炎及早产、胎膜早破、羊膜炎是导致细菌性阴道病的原因， 新生儿感染及产褥感染等严重后果也是引起细菌性阴道病的常见因素[2]。本科于2015年1月～2016年6月联合应用甲硝唑与阴道抑菌凝胶治疗细菌性阴道病， 本文对此进行研究， 报告如下。
1 资料与方法
1. 1 一般资料 选取本院2015年7月～2016年6月收治的细菌性阴道病患者100例。随机将患者分为对照组和治疗组， 各50例。治疗组年龄23～48岁， 平均年龄(32.6±12.8)岁；病程1～16 d， 平均病程(10.3±6.2)d。对照组年龄22～49岁， 平均年龄(33.4±13.1)岁；病程1～18 d， 平均病程(11.2±7.4)d。两组患者一般资料差异无统计学意义(P>0.05)， 具有可比性。
1. 2 诊断标准[3] ①病史：外阴瘙痒或烧灼感及白带增多。②妇科检查：阴道分泌物呈灰白色、稀薄、量多， 常粘附于阴道壁， 伴有鱼腥味。阴道黏膜无充血的炎症表现， 但容易从阴道壁拭去。③实验室检查： 细菌性阴道病细菌性阴道病阳性。, 百拇医药(陈艳 欧阳云英 范建美)