【摘要】 目的 观察放疗联合国产吉西他滨和顺铂治疗晚期非小细胞肺癌(NSCLC)的近期疗效及耐受性。方法 选择42例晚期NSCLC患者,实施放疗联合GP方案治疗，放疗的剂量60～70 Gy/6～7周,同时给予吉西他滨和顺铂化疗(GP方案)。结果 全部患者均完成治疗,全部缓解(CR)6例，部分缓解 (PR)28例，有效率为80.9 %(CR+ PR)。生存质量明显改善。不良反应主要为白细胞及血小板降低,但均能耐受。结论 放疗联合吉西他滨和顺铂治疗晚期非小细胞肺癌近期疗效较好, 能明显提高患者的生活质量,并且毒副反应大多数患者能耐受。

    【关键词】 非小细胞肺癌；放射疗法；化学疗法；吉西他滨

    Radiotherapy and concurrent gemcitabinem plus cisplatinin on advanced non-small cell lung cancer LI Zheng.Department of Radiation,The Chinese Medicine Hospital of Dongping County, Shandong, 271500, China

    【Abstract】 Objective To evaluate the effect and toxicity of radiotherapy and concurrent gemcitabinem plus cisplatinin for advanced non-small cell lung cancer(NSCLC). Methods 42 patients with advanced NSCLC were selected,they were treated by radiotherapy with a total dose of DT60～70 Gy/6～7weeks, and chemotherapy with gemcitabinem and cisplatin. Results 6 patients achieved complete remission(CR)and 28 partial remission(PR). Total response rate was 80.9 %. The main side effects were leucopenia and thrombocytopenia, but they were tolerable. Conclusion The regimen of concurrent gemcitabinem plus cisplatinin and radiotherapy is effective, safe and well-tolerable in the treatment of for advanced NSCLC. ......