不孕症妇女单纯疱疹病毒和巨细胞病毒感染的检测与分析(2)
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孕早期妇女HSV感染对胎儿的危害较大，最主要的影响是致胎儿流产、先天畸形、低体重儿、早产等，其传播途径主要经产道感染,而经胎盘感染导致先天异常的情况极其少见。但近期有学者研究发现，孕早期妇女感染HSV后，在孕晚期胎儿可出现脑损伤和原发性中枢神经系统感染[18,19]。CMV是宫内感染最常见的病毒，孕早期CMV感染是引起胎儿宫内感染和发育缺损的重要原因，特别是易造成出生儿神经性听力丧失[20,21]。本研究早妊组妇女中，HSV和CMV特异性IgM抗体阳性率分别为1.81%和0.90%。因此，积极开展孕早期妇女HSV、CMV感染的筛查工作十分必要，对提高我国人口素质、优生优育具有重大意义。
参 考 文 献
[1] Stagno S, Pass RF, Dworsky ME, et al. Congenital cytomegalovirus infection: the ralatine importance of primary recurrent maternal infection. N Engl J Med,1982,306(16):945-949.
[2] Joseph SA, Beliveau C, Muecke CJ, et al. Risk factors for cytomegalovirus seropositivity in a population of day care educators in Montreal.Canada Occup Med(Lond),2005,55(7):564-567.
[3] Looker KJ, Garnett GP, Schmid GP. An estimate of the global prevalence and incidence of herpes simplex virus type 2 infection. Bull World Health Organ,2008,86(10):805-812.
[4] Weiss H. Epidemiology of herpes simplex virus type 2 infection in the developing world. Herpes,2004,11(suppl 1):24-35.
[5] Li Z, Yan C, Liu P, et al. Prevalence of serum antibodies to TORCH among women before pregnancy or in the early period of pregnancy in Beijing. Clin Chim Acta,2009,403(1-2):212-215.
[6] 闻良珍，吴圣楣，吕绳敏，等.三城市孕妇人巨细胞病毒感染及其母婴传播的流行病学调查. 中华妇产科杂志,1996,31(2):714-717.
[7] Steiner I, Spivack JG, Deshmane SL, et al. A herpes simplex virus type 1 mutant containing a nontransinducing Vmw65 protein establishes latent infection in vivo in the absence of viral replication and reactivates efficiently from explanted trigeminal ganglia. J Virol,1990,64(4):1630-1638.
[8] Reddehase MJ, Balthesen M, Rapp M, et al. The conditions of primary infection define the load of latent viral genome in organs and the risk of recurrent cytomegalovirus disease ......
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