中药自热帖敷穴位治疗儿童哮喘缓解期的临床观察(1)
摘要 目的：研究中藥自热帖敷穴位治疗儿童哮喘缓解期的临床疗效。方法：选取2013年2月至2014年8月广西玉林市中医医院收治的哮喘缓解期患儿86例。以随机数字表法均分为观察组与对照组。对照组予以常规西医治疗，观察组则予以中药自热贴敷穴位治疗。分别比较2组临床疗效，治疗前后各项临床症状改善情况，治疗前后免疫功能指标水平，治疗前后血清白细胞介素-13(IL-13)、巨噬细胞炎性蛋白-1α(MIP-1α)及淀粉样蛋白A(SAA)水平。结果：观察组临床总有效率为95.35%(41/43)，相比对照组的69.77%(30/43)更高(P<0.05)。治疗后观察组哮喘发作程度、哮喘发作频度、反复感冒以及自汗积分分别为(1.08±0.51)分、(1.09±0.42)分、(1.08±0.71)分、(0.94±0.61)分，均明显低于对照组的(1.78±0.74)分、(1.83±0.55)分、(1.53±0.74)分、(1.44±0.70)分(均P<0.05)。治疗后观察组IgM、IgG、IgA水平分别为(1.94±0.72)mg/mL、(16.12±0.74)mg/mL、(2.32±0.47)mg/mL，均明显高于对照组的(1.62±0.57)mg/mL、(13.49±0.68)mg/mL、(1.77±0.36)mg/mL(均P<0.05)。治疗后观察组与对照组血清IL-13、MIP-1α及SAA水平均明显低于治疗前，而观察组又明显低于对照组(均P<0.05)。结论：中药自热帖敷穴位治疗儿童哮喘缓解期的临床疗效显著，有利于改善患儿临床症状，提高免疫功能，同时有效改善血清IL-13、MIP-1α及SAA水平。
关键词 哮喘缓解期；儿童；中药自热贴敷；穴位治疗；免疫功能
AbstractObjective：TostudythecurativeeffectsoftraditionalChinesemedicinehotcompressfromacupointinthetreatmentofchildrenwithasthmainremissionstage.Methods：FromFebruary2013toAugust2014inourhospital，86casesofchildrenwithasthmainremissionstagewererandomlydividedintoexperimentalgroupandcontrolgroup.Thecontrolgroupreceivedconventionalwesternmedicinetreatment，andtheexperimentalgroupwastreatedwithtraditionalChinesemedicinehotcompressacupuncturetreatment.Theefficacy，theimprovementofclinicalsymptoms，theimmunefunctionindexesofseruminterleukin-13(IL-13)，macrophageinflammatoryprotein1α(MIP-1α)andserumamyloidAprotein(SAA)leveloftwogroupsbeforeandaftertreatmentwerecompared.Results：Thetotaleffectiverateoftreatmentgroupwas95.35%(41/43)，whichwashigherthanthecontrolgroup69.77%(30/43)(P<0.05).Afterthetreatment，degreeofasthmagroup，thefrequencyofasthmaattacks，repeatedcoldsandsweatingscorewas(1.08±0.51)，(1.09±0.42).(1.08±0.71)，(0.94±0.61)，whichweresignificantlylowerthanthecontrolgroup(1.78±0.74)，(1.83±0.55)，(1.53±0.74)，(1.44±0.70)(P<0.05).TheexperimentalgroupofIgM，IgG，IgAaftertreatmentwere(1.94±0.72)mg/mL，(16.12±0.74)mg/mL，(2.32±0.47)mg/mL，whichweresignificantlyhigherthanthoseincontrolgroup(1.62±0.57)mg/mL，(13.49±0.68)mg/mL，(1.77±0.36)mg/mL(P<0.05).TheserumIL-13，MIP-1αandSAAlevelsoftheexperimentalgroupandthecontrolgroupweresignificantlylowerthanbeforetreatment，whiletheexperimentalgroupwassignificantlylowerthanthecontrolgroup(P<0.05).Conclusion：ThetraditionalChinesemedicinehotcompressacupointinthetreatmentofchildrenwithasthmainremissionstageshowedclinicalcurativeeffect，whichisbeneficialtoimprovetheclinicalsymptoms，improveimmunefunction，andeffectivelyimprovethelevelofserumIL-13，MIP-1αandSAA.
KeyWordsAsthmainremissionperiod；Children；Chinesemedicinehotcompress；Acupointtherapy；Immunefunction, 百拇医药(刘光武李原蔡雯李明党英)
关键词 哮喘缓解期；儿童；中药自热贴敷；穴位治疗；免疫功能
AbstractObjective：TostudythecurativeeffectsoftraditionalChinesemedicinehotcompressfromacupointinthetreatmentofchildrenwithasthmainremissionstage.Methods：FromFebruary2013toAugust2014inourhospital，86casesofchildrenwithasthmainremissionstagewererandomlydividedintoexperimentalgroupandcontrolgroup.Thecontrolgroupreceivedconventionalwesternmedicinetreatment，andtheexperimentalgroupwastreatedwithtraditionalChinesemedicinehotcompressacupuncturetreatment.Theefficacy，theimprovementofclinicalsymptoms，theimmunefunctionindexesofseruminterleukin-13(IL-13)，macrophageinflammatoryprotein1α(MIP-1α)andserumamyloidAprotein(SAA)leveloftwogroupsbeforeandaftertreatmentwerecompared.Results：Thetotaleffectiverateoftreatmentgroupwas95.35%(41/43)，whichwashigherthanthecontrolgroup69.77%(30/43)(P<0.05).Afterthetreatment，degreeofasthmagroup，thefrequencyofasthmaattacks，repeatedcoldsandsweatingscorewas(1.08±0.51)，(1.09±0.42).(1.08±0.71)，(0.94±0.61)，whichweresignificantlylowerthanthecontrolgroup(1.78±0.74)，(1.83±0.55)，(1.53±0.74)，(1.44±0.70)(P<0.05).TheexperimentalgroupofIgM，IgG，IgAaftertreatmentwere(1.94±0.72)mg/mL，(16.12±0.74)mg/mL，(2.32±0.47)mg/mL，whichweresignificantlyhigherthanthoseincontrolgroup(1.62±0.57)mg/mL，(13.49±0.68)mg/mL，(1.77±0.36)mg/mL(P<0.05).TheserumIL-13，MIP-1αandSAAlevelsoftheexperimentalgroupandthecontrolgroupweresignificantlylowerthanbeforetreatment，whiletheexperimentalgroupwassignificantlylowerthanthecontrolgroup(P<0.05).Conclusion：ThetraditionalChinesemedicinehotcompressacupointinthetreatmentofchildrenwithasthmainremissionstageshowedclinicalcurativeeffect，whichisbeneficialtoimprovetheclinicalsymptoms，improveimmunefunction，andeffectivelyimprovethelevelofserumIL-13，MIP-1αandSAA.
KeyWordsAsthmainremissionperiod；Children；Chinesemedicinehotcompress；Acupointtherapy；Immunefunction, 百拇医药(刘光武李原蔡雯李明党英)
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